Thursday, May 14, 2020

List Of Common Genes Of ADHD, Asd ( ASD ) - 780 Words

RESULTS: 1. Results from MalaCards: With the help of GeneCardsSuite, a list of genes was retrieved. For ADHD, 67 genes were reported, 39 for ID, 86 for ASD and out 242 only top 100 closely related genes were taken for SZ (Table.1). Further common genes were isolated for multiple disorders. A list of common genes can be seen in the Table.2. 2. Results from: STRING: An interaction pattern of 10 common genes among ADHD, SZ, ASD, was analyzed (Figure 13). Interactions in STRING are derived from five main sources, which include, genomic Context Predictions, High-throughput Lab Experiments, (Conserved) Co-Expression, Automated Textmining, Previous Knowledge in Databases. Out of the above mentioned sources, only experimentally evident†¦show more content†¦5. Results from Molinspiration: With the help of ‘Canonical SMILES’ of phytochemicals taken from PubChem, virtual screening was performed. All the phytochemicals which followed the Lipinski’s rule of five were shortlisted, as shown in Table.9 6. Target genes: After the careful analyzation of results from STRING and GeneMANIA, SLC6A3 and DRD2 genes were found to be majorly responsible for the cause of Attention Deficit Hyperactivity Disorder, Schizophrenia, and Autism Spectrum Disorder. This could be seen Table.5 7. Target Pathway: â€Å"Dopaminergic synapse† pathway was found to possess the involvement of genes SLC6A3 (Dopamine Activated Transporter) and DRD2 (D2: Dopamine receptor2). Figure.18 displays the pathway shared by the common genes of ADHD, ASD, SZ. 8. Modeled target proteins: With the help of MODELLER 9.18, DAT (Dopamine transporter) and D2 (Dopamine receptor) were modeled. Out of the 5 modeled structures of each, the best were selected on the basis of lowest DOPE score, as shown in Table 6 and 7 respectively. The models were viewed via RasMol shown in figure 19 and 20. 9. Docking result: Target protein Dopamine Activated transporter (SLC6A3) was chosen and 5 best ligands according to the Molinspiration result were selected for docking process with AutoDock vina, MGLTools1.5.6. Figure 21-25 display the interaction between ligand and reseptor via Discovery studio visualizer. It was found that Oroxylin A from theShow MoreRelatedIntroduction. Managing Autism Can Be A Challenge To Cope1397 Words   |  6 PagesIntroduction Managing autism can be a challenge to cope with in any family with-out understanding ASD. In the article, Autism Spectrum Disorder, Catherine Lord explains autism spectrum disorder, or ASD, as a neurodevelopmental syndrome that is defined by deficits in social reciprocity and communication, and by unusual restricted, repetitive disorder (2000. P355). Parenting a child on the autism spectrum is difficult for any parent who is uneducated about the specific disorder their child is facedRead MoreUnderstanding Autism And The Different Disorders On The Autism Spectrum1225 Words   |  5 Pagesdamage. FXS is the most common inherited cause of intellectual disabilities and is strongly linked to the Autism Spectrum Disorder (ASD) on a behavioral and molecular level (Hagerman et al., 2009). The change or mutation on the X chromosome that causes FXS is called the Fragile X Mental Retardation-1 gene or the FMR-1 gene. The FMR-1 gene is found in every cell in the body. The protein that this gene produces is vital to correct human development. With FXS the FMR-1 gene either makes too littleRead MoreAsperger’s Syndrome: Madness, Savantism, or Genius2985 Words   |  12 PagesPsychiatrists’ Academic Psychiatry that the â€Å"genes linked to Asperger’s were the same as those associated with creativity and genius†. However, there is no empirical evidence of this. There are several a few theories, though, of the cause of this disorder, which are presented in the research section of this paper. Asperger’s Syndrome – Characteristics There are many theories and continuing debate about whether or not Asperger’s and other conditions (such as ADHD-Attention Deficit Hyperactivity Disorder)

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